CD41 Rabbit Monoclonal Antibody(ARA842)
Key features and details
- Reactivity:Human
- Application:WB, IHC-P
- Host:Rabbit
- Clonality:Monoclonal
- lsotype:IgG
- Target:CD41
-
Brand:
CAT.NO. : ARA6657
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Product Details
Background
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Application
|
Application |
Dilution Ratio |
|
WB |
1:500 - 1:2,000 |
|
IHC-P |
1:50 - 1:200 |
Overview
|
Item |
Details |
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human CD41 aa 41 - 74 / 1039. |
|
Species Reactivity |
Human |
|
Validated Applications |
WB, IHC - P |
|
Molecular Weight |
Predicted band size: 113 kDa |
|
Positive Control |
Human placenta tissue lysates, human tonsil tissue, human spleen tissue. |
|
Conjugation |
unconjugated |
|
RRID |
AB_3070394 |
|
Form |
Liquid |
|
Concentration |
1ug/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified. |
Data
Western blot analysis of CD41 on human placenta tissue lysates.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD41 antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue with Rabbit anti-CD41 antibody at 1/100 dilution.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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