CD42b Mouse Monoclonal Antibody(ARA860)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:CD42b

Brand:

CAT.NO. : ARA6686

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Size:

1mL

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Product Details

Background

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.

Application

Application	Dilution Ratio
IHC-P	1:200-1:1,000

Overview

Antibody Type	Recombinant Mouse Monoclonal Antibody
Immunogen	Recombinant protein within human CD42b aa 100 - 350 / 652
Species Reactivity	Human
Validated Applications	IHC-P
Molecular Weight	Predicted band size: 72 kDa
Positive Control	Human bone marrow tissue, human spleen tissue
Conjugation	unconjugated
Form	Liquid
Concentration	1ug/ul
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG1
Purification Method	Protein A affinity purified