CD44v6 Mouse Monoclonal Antibody(ARA950)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- Target:CD44v6
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Brand:
CAT.NO. : ARA6791
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Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
Background
The protein expressed by gene CD44 functions as a cell-surface receptor involved in cell-cell interactions, cell adhesion, and migration, allowing cells to detect and react to changes in their tissue microenvironment. It is implicated in numerous cellular processes, including the activation, recirculation, and homing of T-lymphocytes, hematopoiesis, inflammation, and the response to bacterial infection. Through its ectodomain, CD44 interacts with extracellular matrix components like hyaluronan, collagen, growth factors, cytokines, and proteases, serving as a platform for signal transduction by forming protein complexes with receptor kinases and membrane proteases via its cytoplasmic domain. Effectors such as PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases, and phospholipase C coordinate signaling pathways that promote calcium mobilization and actin-mediated cytoskeleton reorganization crucial for cell migration and adhesion. This supplementary information is collated from multiple sources and compiled automatically.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:1000 |
Overview
|
Host Species |
Mouse |
|
Clonality |
Monoclonal |
|
Isotype |
IgG1 |
|
Carrier-Free |
No |
|
Reactivity Species |
Human |
|
Application |
IHC-P |
|
Immunogen |
The exact immunogen used to generate this antibody is proprietary information. |
Data
Immunohistochemical staining of human breast carcinoma tissue using CD44v6 Mouse Monoclonal Antibody(ARA950)
Immunohistochemical staining of human breast tissue using CD44v6 Mouse Monoclonal Antibody(ARA950)
Immunohistochemical staining of human skin tissue using CD44v6 Mouse Monoclonal Antibody(ARA950)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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