CD45RO Mouse Monoclonal Antibody(ARA936)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- Target:CD45RO
-
Brand:
CAT.NO. : ARA6774
RMB Please choose
RMB Please choose
Product Details
Background
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA). PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells, particularly lymphocytes. It plays a key role in the activation and differentiation of T cells, B cells, and other immune cells by modulating signaling pathways. It functions by dephosphorylating specific tyrosine residues on target proteins, thereby controlling various signaling processes essential for immune response and homeostasis. Naive T lymphocytes are typically positive for CD45RA, which includes only the A protein region. Activated and memory T lymphocytes express CD45RO, the shortest CD45 isoform, which lacks all three of the A, B, and C regions. This shortest isoform facilitates T cell activation.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:1000-1:4000 |
Overview
|
Antibody Type |
Recombinant Mouse Monoclonal Antibody |
|
Species Reactivity |
Human |
|
Validated Applications |
IHC-P, FC |
|
Molecular Weight |
Predicted band size: 131 kDa |
|
Positive Control |
Human colon cancer tissue, human liver tissue, human spleen tissue, human peripheral blood cells |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG1 |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human spleen tissue using CD45RO Mouse Monoclonal Antibody(ARA936)
Immunohistochemical staining of human colon cancer tissue using CD45RO Mouse Monoclonal Antibody(ARA936)
Immunohistochemical staining of human liver tissue using CD45RO Mouse Monoclonal Antibody(ARA936)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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