CD6 Mouse Monoclonal Antibody(ARA993)

Key features and details

Reactivity:Human
Application:IHC, IF/ICC
Host:Mouse
Clonality:Monoclonal
Target:CD6

Brand:

CAT.NO. : ARA6898

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Size:

1mL

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Product Details

Background

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.

Application

Application	Dilution Ratio
IHC-P	1:200-1:500

Overview

Antibody Type	Mouse Monoclonal Antibody
Immunogen	Purified recombinant fragment of human CD6 (AA: 18-199) expressed in E.Coli.
Species Reactivity	Human
Validated Applications	IHC-P, IF-Cell, FC
Molecular Weight	72 kDa
Positive Control	Human CD6 recombinant protein, CD6-hIgGFc transfected HEK293 cell lysate, human breast cancer tissue, human rectum cancer tissue, Hela.
Conjugation	unconjugated
Form	Liquid
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.
Isotype	IgG2b
Purification Method	Protein A affinity purified.