CD90 Rabbit Monoclonal Antibody(ARB588)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:CD90

Brand:

CAT.NO. : ARB6880

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Size:

1mL

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Product Details

Background

CD90(THY1) is a 25-37-kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein. It has been found to regulate cell adhesion, migration, apoptosis, axon growth, cell-cell and cell-matrix interactions, T-cell activation, and fibrosis. Several reports have shown that CD90 has an important role in cancer in regulating cancer cell proliferation, metastasis, and angiogenesis. CD90 is usually expressed on thymocytes, mesenchymal stem cells, hematopoietic stem cells, natural killer cells, neurons, endothelial cells, renal glomerular mesangial cells, follicular dendritic cells, fibroblasts, and myofibroblasts. CD90 is an important prognostic marker in many cancers, such as gastric cancer and colon cancer, et al. Consequently, therapies that target CD90 have great promise in treating many cancers. However, several studies also indicate a contradictory role for CD90, where it acts as a tumor suppressor, such as ovarian adenocarcinoma, nasopharyngeal carcinoma, and neuroblastoma.

Application

Application	Dilution Ratio
IHC-P	1:100-1:200

Overview

Predicted Molecular Wt	18kDa
Species Cross-reactivity	Human
Applications	IHC-P
Purity	ProA affinity purified IgG
Form	Liquid
Swissprot ID	P04216
Subcellular location	Cytoplasm and membrane
Recommended Method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes.
Immunogen	Synthetic peptide.
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%