CDX2 Rabbit Monoclonal Antibody(ARA757)
Key features and details
- Target:
- Clone ID:
- Host:
- Clone Type:
- Purity:
- Species Cross-reactivity:
- Applications:
- Isotype:
-
Brand:
CAT.NO. : ARA6544
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
Background
CDX2 is a homeobox gene encoding nuclear homeodomain transcriptional factor essential to intestinal organogenesis. CDX2 is crucial for differentiation of epithelium in the intestine, pancreas and biliary tract. CDX2 interacts with the tumour suppressor genes APC and E-cadherin, as well as bcl-2.In the intestine (from duodenum to rectum) CDX2 nuclear protein is demonstrated strongly and uniformly in all types of epithelial cells. In pancreas and biliary tract CDX2 protein is demonstrated in scattered ductal cells. In tumor tissues, CDX2 is positive in the large majority cases of colorectal and appendiceal adenocarcinomas.CDX2 is a relatively sensitive and specific marker for “intestinal” adenocarcinomas. In the classification of (adeno-)carcinomas of the unknown primary, CDX2 is an important marker but should always be included in a panel. Also in order to identify the origin of neuroendocrine tumors, CDX2 is useful in a panel.
Application
|
Application |
Dilution Ratio |
|
WB |
1:1,000-1:2,000 |
|
IHC-P |
1:100-1:200 |
Overview
|
Host Species |
Rabbit |
|
Species Cross-reactivity |
Human |
|
Application |
WB, IHC-P |
|
Immunogen |
A synthetic peptide corresponding to residues on the N-terminus of human CDX2 |
|
Purity |
ProA affinity purified IgG |
|
Clone Type |
Recombinant Monoclonal |
|
Isotype |
IgG |
|
Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA |
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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