CK8/18 Rabbit Monoclonal Antibody Cocktail(ARB855/ARB856)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6647
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Size:
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Product Details
Background
Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner cytokeratin 8, perhaps the most commonly found products of the intermediate filament gene family. In some epithelial cell types, cytokeratin 8 and cytokeratin 18 are the sole keratins present. The classical example is the liver, with cytokeratin 8/cytokeratin 18 representing the characteristic and only keratin pair of normal hepatocytes. The same is true for other highly specialized parenchymatous epithelia such as acinar cells of the pancreas, proximal tubular epithelial cells of the kidney, and certain endocrine cells such as pancreatic islet cells. Furthermore, cytokeratin 8/cytokeratin 18 occur together with other keratins—in various pseudostratified (e.g. respiratory) and complex (e.g. glandular) epithelia and in the urothelium; in these composite epithelial tissues, cytokeratin 8 and cytokeratin18 are often most prominent in the lumenlining cells. Even in non-keratinizing stratified squamous epithelia, cytokeratin 8 and cytokeratin 18 may be focally expressed in the basal cell layer, together with cytokeratin 19 and the constitutive stratified-epithelial keratins.
Overview
| Target | Cytokeratin 8&18 |
| Host Species | rabbit monoclonal antibodyCocktail |
| Molecular Weight | 54/48 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P05787/P05783 |
| Immunogen | Synthetic peptides of cytokeratin 8 and 18 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:50-1:100 |
| Subcellular Location | Cytoplasm |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 minutes |
Data
Immunohistochemical staining of human colonic tissue sections using CK8/18 Rabbit Monoclonal Antibody Cocktail (ARB855/ARB856)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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