Claudin 1 Rabbit Monoclonal Antibody(ARA862)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:Claudin 1

Brand:

CAT.NO. : ARA6688

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Size:

1mL

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Product Details

Background

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. Acts as a co - receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1 - CD81 receptor complex is essential for HCV entry into host cell.

Application

Application	Dilution Ratio
IHC-P	1:1000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Recombinant full length protein within human Claudin 1
Species Reactivity	Human
Validated Applications	WB, IHC-R, IF-Tissue, IF-Cell
Molecular Weight	Predicted band size: 23 kDa
Positive Control	A431 cell lysates, A431, HepG2, human tonsil tissue, human skin tissue
Conjugation	unconjugated
RRID	AB_3072367
Form	Liquid
Concentration	1μg/ul
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified