Claudin 18.2 Mouse Monoclonal Antibody(ARA848)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- Target:Claudin 18.2
-
Brand:
CAT.NO. : ARA6672
RMB Please choose
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Product Details
Background
Claudin18.2 (CLDN18.2) is a splice variant of the membrane epithelial tight junctions protein Claudin18 (CLDN18) and has been identified as a promising biomarker for targeted therapy. While upon malignant transformation, the changes in cell polarity lead to the exposure of CLDN18.2 epitopes, which are suitable for targeted therapy. Prior evidence demonstrates that except for GC, CLDN18.2 is aberrantly expressed in various primary tumors and metastases, including pancreatic, biliary, ovarian, and lung adenocarcinomas, which makes CLDN18.2 a pan-cancer target. CLDN18.2 has a restricted expression profile in normal tissues, it physiologically expresses only in the tight junction supramolecular complex of gastric mucosa.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:50 - 1:100 |
Overview
| Antibody Type | Mouse Monoclonal Antibody |
| Immunogen | Recombinant protein |
| Species Reactivity | Human |
| Validated Applications | IHC-P |
| Molecular Weight | Predicted band size: 28 kDa |
| Positive Control | Human stomach cancer tissue |
| Conjugation | unconjugated |
| Form | Liquid |
| Storage Buffer | PBS (pH7.4), 0.1% BSA. Preservative: 0.05% Sodium Azide |
| Isotype | IgG |
| Purification Method | Protein A affinity purified |
Data
Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue with Mouse anti-Claudin 18.2 antibody at 1/50 dilution.
Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue with Mouse anti-Claudin 18.2 antibody at 1/50 dilution.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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