Claudin 6 Rabbit Monoclonal Antibody(ARB921)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6713
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Size:
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Product Details
Background
Claudin-6 is a member of the CLDN family that is expressed in epithelial cell sheets. Downregulation of Claudin-6 has been reported in breast invasive ductal carcinoma associated with lymphatic metastasis which may point to a function of Claudin-6 as a tumor suppressor. Claudin-6 is reported to play a role in inhibiting malignancy of breast cancer cells by inducing apoptosis, inhibiting proliferation and migration. Claudin6 is rarely expressed in normal tissue species, but is highly expressed in tumor cells, especially in ovarian cancer.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 23kDa |
| Species Cross-reactivity | Human |
| Applications | IHC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | P56747 |
| Subcellular location | Membrane & Cytoplasm |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Immunohistochemical staining of human ovarian carcinoma tissue using Claudin 6 Rabbit Monoclonal Antibody (ARB921).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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