Claudin18.2 Rabbit Monoclonal Antibody(ARB922)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6714
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Claudin18.2 (CLDN18.2) is a splice variant of the membrane epithelial tight junctions protein Claudin18 (CLDN18) and has been identified as a promising biomarker for targeted therapy. While upon malignant transformation, the changes in cell polarity lead to the exposure of CLDN18.2 epitopes, which are suitable for targeted therapy. Prior evidence demonstrates that except for GC, CLDN18.2 is aberrantly expressed in various primary tumors and metastases, including pancreatic, biliary, ovarian, and lung adenocarcinomas, which makes CLDN18.2 a pan-cancer target. CLDN18.2 has a restricted expression profile in normal tissues, it physiologically expresses only in the tight junction supramolecular complex of gastric mucosa.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 28kDa |
| Species Cross-reactivity | Human |
| Applications | IHC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | P56856-2 |
| Subcellular location | Membrane |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
| Immunogen | Recombinant protein fragment of human Claudin18.2 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
Research Use Only
New Products
