Clusterin Rabbit Monoclonal Antibody(ARB924)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6716
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Size:
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Product Details
Background
Clusterin functions as extracellular chaperone that prevents aggregation of nonnative proteins. It also functions as extracellular chaperone that prevents aggregation of nonnative proteins. It's intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Clusterin is detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. It's also detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung. Clusterin has been shown to stain 95% of systemic ALCL, including 100% of ALK-1(+) and 91% of ALK-1(-) ALCL. Studies have shown that clusterin may be a useful diagnostic marker for ALCL, especially in ALK-1(-) cases. Overexpression of clusterin appears to be a useful prognostic factor for patients with ovarian carcinomas.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 52kDa |
| Species Cross-reactivity | Human |
| Applications | IHC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | P10909 |
| Subcellular location | Secreted |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Immunohistochemical staining of human tonsil tissue using Clusterin Rabbit Monoclonal Antibody (ARB924).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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