COL4A3 Rabbit Monoclonal Antibody(ARB927)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6719
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Size:
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Product Details
Background
Six α chain of Type IV collagen can aggregate into 3 triple helix molecular structure, which called monomer, monomer polymerization to form a dimer or tetramer, which can twist each other to form a collagen network structure. Mutations in the X-linked dominant Alport comprehensive acquisition gene mainly occurred in the gene encoding collagen type IV α5 chain (COL4A5). Mutations in the autosomal recessive Alport syndrome occur on chromosome 2 in genes encoding collagen type IV α3 or α4 strands (COL4A3/COL4A4). COL4A3 is mainly expressed in podocytes in Bowman's capsule of glomeruli.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 162kDa |
| Species Cross-reactivity | Human |
| Applications | IHC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | 001955 |
| Subcellular location | Basement membrane |
| Recommended Method | High temperature and high pressure induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. Amplifier for Mouse + Rabbit IgG for 25min, HRP Polymer Detector for 25 min. |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Immunohistochemical staining of human kidney tissue using COL4A3 Rabbit Monoclonal Antibody (ARB927).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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