CTAG1A/NY-ESO-1 Rabbit Monoclonal Antibody

Key features and details

Reactivity:Human
Application:IHC - P
Host:Rabbit
Clonality:Monoclonal
lsotype:IgG
Target:CTAG1B

Brand:

CAT.NO. : ARA6621

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Size:

1mL

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Product Details

Background

CTAG1B (cancer/testis antigen 1), also known as NY-ESO-1 (Autoimmunogenic cancer/testis antigen) is an 18 kDa protein with putative roles in germ cell self-renewal and/or differentiation. Of cancer/testis (CT) antigens, CTAG1B is the most immunogenic CT antigen known to date. CTAG1B staining is predominantly cytoplasmic with focal nuclear expression. Tissue distribution is highly restricted in the normal adult; it is only detected in spermatogonia and primary spermatocytes within the testis. Surrounding non-gametogenic cells, including Sertoli cells and spermatids are negative. CTAG1B is also undetected in the ovaries. However, expression is observed in germ cells of the fetal testis and ovaries. In cancer, genome wide demethylation was shown to induce CTAG1B expression. Immunohistochemical expression has been demonstrated commonly in myxoid and round cell liposarcoma (89-100%), neuroblastoma (82%), synovial sarcoma (80%), melanoma (46%) and epithelial ovarian cancer (43%). Staining in lung, esophageal, liver, gastric, and bladder cancers has also been noted with lower prevalence. Immunoreactivity was only observed in tumor cells; no staining was present in adjacent cells. Furthermore, previous studies have correlated CTAG1B antigen expression with advance stage of disease and indicated a subset of more aggressive tumors that may be less susceptible to known treatments. CTAG1B antibody has been used for identification of myxoid and round cell liposarcoma.

Application

Applications	Dilution
IHC-P	1:1,000-1:2,000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Recombinant full length protein corresponding to Human CTAG1B
Species Reactivity	Human
Validated Applications	IHC-P
Molecular Weight	Predicted band size: 18 kDa
Positive Control	Human testis tissue, human stomach carcinoma tissue
Conjugation	unconjugated
RRID	AB_3072324
Form	Liquid
Concentration	1ug/ul
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified