CXCR5 Rabbit Monoclonal Antibody(ARB931)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6723
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Size:
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Product Details
Background
Initially discovered in 1992 as Burkitt's lymphoma receptor 1, CXCR5 (also known as CD185) is a seven-transmembrane G protein-coupled receptor (GPCR) protein, which plays fundamental roles in inflammatory, infectious and immune responses. CXCR5 is expressed in mature B-cells and Burkitt's lymphoma. CXCR5 is highly expressed in primary and secondary follicles within gastric lymphomas. Higher CXCR5 expression and migration by non-small cell lung cancer (NSCLC) cells suggest a role in migration and metastasis of primary lung tumors in response to CXCL13. It has been proposed that CXCR5/CXCL13, either alone or in combination, could be used as a prognostic biomarker for lung cancer. Other studies have shown that CXCR5 overexpression in breast cancer patients highly correlates with lymph node metastases, and elevated CXCR5 antibody expression may contribute to abnormal cell survival and migration in breast tumors that lack functional p53 protein. Another study has indicated that prostate cancer tissue as well as cell lines express higher non-basal levels of CXCR5 and found a correlation between the level of CXCR5 and Gleason score. CXCR5 location was additionally considered and higher Gleason scores correlated with nuclear CXCR5 while cytoplasmic and membrane CXCR5 correlated with benign and early prostate cancers.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 42kDa |
| Species Cross-reactivity | Human |
| Applications | IHC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | P32302 |
| Subcellular location | Membrane/cytoplasm |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Immunohistochemical staining of human tonsil tissue using CXCR5 Rabbit Monoclonal Antibody (ARB931).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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