Cytokeratin 16 Rabbit Monoclonal Antibody(ARA855)

Key features and details

  • Reactivity:Human
  • Application:IHC
  • Host:Rabbit
  • Clonality:Monoclonal
  • Target:Cytokeratin 16
  • Brand:
CAT.NO. : ARA6681
RMB Please choose
RMB Please choose
Size:
1mL
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).
Application

Application

Dilution Ratio

IHC-P

1:50-1:1,500

Overview

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Synthetic peptide within human Cytokeratin 16 aa 27 - 75 / 473

Species Reactivity

Human

Molecular Weight

Predicted band size: 51 kDa

Positive Control

HeLa cell lysate, HaCaT cell lysate, HepG2 cell lysate, MCF7 cell lysate, A431, human esophagus tissue, human tonsil tissue, human lung carcinoma tissue, human breast carcinoma tissue, human breast tissue

Conjugation

unconjugated

RRID

AB_3069900

Form

Liquid

Concentration

1ug/ul

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide

Isotype

IgG

Purification Method

Protein A affinity purified

Data

Immunohistochemical analysis of paraffin-embedded human esophagus tissue with Cytokeratin 16 Rabbit Monoclonal Antibody(ARA855).

Immunohistochemical analysis of paraffin-embedded human tonsil tissue using Cytokeratin 16 Rabbit Monoclonal Antibody(ARA855).

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Cytokeratin 16 Rabbit Monoclonal Antibody(ARA855).

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cytokeratin 16 Rabbit Monoclonal Antibody(ARA855).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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