Cytokeratin 17 Rabbit Monoclonal Antibody(ARB936)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6728
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Cytokeratin 17 (CK17) is 48 kD intermediate filament found in simple epithelia and is a marker for cervical reserve (stem) cells. CK17 can be useful in the identification of uterine cervical squamous lesions including atypical immature metaplasia, cervical intraepithelial neoplasia, and cervical squamous carcinoma. CK17 also assists in the differentiation of oral squamous cell carcinoma. CK17 staining occurs in human epithelial appendages such as hair follicles. Studies indicate CK17 maybe an excellent marker for the identification of squamous cell carcinomas in various tissues including the cervix, lung and oral cavity. CK17 may also be helpful in distinguishing myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. Positive expression of CK17 in breast cancer has been associated with a worse prognosis, high tumor grade and positive axillary lymph nodes. Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 48kDa |
| Species Cross-reactivity | Human |
| Applications | IHC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | Q04695 |
| Subcellular location | Cytoplasmic |
| Recommended method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
| Immunogen | Synthetic peptide corresponding to residues within aa400-500 of Human Cytokeratin 17 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Immunohistochemical staining of human esophageal carcinoma tissue using Cytokeratin 17 Rabbit Monoclonal Antibody (ARB936).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
