Cytokeratin 5&6 Rabbit Monoclonal Antibody(ARA943)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:Cytokeratin 5&6
-
Brand:
CAT.NO. : ARA6784
RMB Please choose
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:1,000 |
Overview
|
Antibody Type |
Recombinant Rabbit Monoclonal Antibody |
|
Immunogen |
Synthetic peptide within human Cytokeratin 6 186 - 235 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
IHC-P, IF-Tissue, WB |
|
Molecular Weight |
Predicted band size: 60 kDa |
|
Positive Control |
Human breast tissue, mouse skin tissue, rat skin tissue, mouse brain tissue lysate, rat brain tissue lysate, human lung squamous cell carcinoma tissue, human skin tissue, human tonsil tissue |
|
Conjugation |
unconjugated |
|
Clone Number |
PSH0-67 |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human breast tissue using Cytokeratin 5&6 Rabbit Monoclonal Antibody(ARA943)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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