DLL4 Rabbit Polyclonal Antibody

Key features and details

Reactivity:Human, Mouse, Rat
Application:WB
Host:Rabbit
Clonality:Polyclonal
Target:DLL4

Brand:

CAT.NO. : ARA6645

RMB Please choose

Size:

50μL 100μL

Trail, Bulk size or Custom requests Please contact us

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Product Details

Background

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

Application

Application	Dilution Ratio
WB	1:500 - 1:2000

Overview

Product Description	Rabbit polyclonal antibody to DLL4
Immunogen	Recombinant fusion protein of human DLL4. The exact sequence is proprietary.
Purification Method	The antibody was purified by immunogen affinity chromatography.
Clonality	Polyclonal
Product Form	Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Gene Name	DLL4
Related Names	Delta - like protein 4; Drosophila Delta homolog 4; Delta4
Gene ID (Human)	54567
Gene ID (Mouse)	54485
Protein ID (Human)	Q9NR61
Protein ID (Mouse)	Q9JI71