Ep-CAM/Ber-EP4 Mouse Monoclonal Antibody(ARM912)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG1
- Target Name:EpCAM
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Brand:
CAT.NO. : ARM6880
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Product Details
Background
Epithelial Cell Adhesion Molecule (EpCAM) is a transmembrane glycoprotein that mediates cell - cell adhesion in epithelia. It is normally present on most baso - lateral surfaces of normal epithelial cells and is absent in myoepithelial cells, hepatocytes, adult squamous epithelia, mesothelial cells, and fibroblasts. Anti - EpCAM stains most adenocarcinomas and neuroendocrine tumours, including small cell carcinomas. A minority of renal clear cell carcinoma, renal oncocytoma, and hepatocellular carcinoma stain positively for EpCAM, while Anti - EpCAM stains nearly all basal cell carcinoma. Anti - EpCAM stains chromophobe renal cell carcinoma, papillary renal cell carcinoma, and cholangiocarcinoma more frequently. Anti - EpCAM can be useful for distinguishing malignancy in the peritoneal and pleural cavities.
Application
IHC: 1:50-1:200
Overview
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Host | Mouse |
| Species Reactivity | Human |
| Form/Format | Tris Buffer, pH7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human colon sections labeling EpCAM with ARM912.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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