EZH2 Rabbit Monoclonal Antibody(ARB951)

Key features and details

Target: EZH2
Clone ID: ARB951
Host: Rabbit
Molecular Weight: 85 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Swissprot ID: Q15910

Brand:

CAT.NO. : ARB6743

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Size:

1mL

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Product Details

Background

EZH2 belongs to polycomb group (PcG). It is the catalytic subunit of the PRC2/EED - EZH2 complex, which methylates 'Lys - 9' (H3K9me) and 'Lys - 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. EZH2 displays a preference for substrates with less methylation. The PRC2/EED - EZH2 complex may also serve as a recruiting platform for DNA methyltransferases.

EZH2 is expressed in many tissues. In the ovary, EZH2 is expressed in primordial follicles and oocytes and also in external follicle cells. EZH2 is overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis. The high expression of EZH2 is closely related to the malignant process, invasiveness and metastasis ability of tumors. EZH2 may be a new marker and therapeutic target for lymphoma.

Overview

Target	EZH2
Host Species	rabbit monoclonal antibody
Molecular Weight	85 kDa
Purity	ProA affinity purified IgG
Species Cross-reactivity	Human
Form	Liquid
Applications	IHC-P
Swissprot ID	Q15910
Immunogen	Recombinant protein fragment
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%
Storage Conditions	-25°C to -18°C
Dilutions	IHC-P: 1:100-1:200
Subcellular Location	Nucleus
Recommended Method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 min