EZHIP Rabbit Monoclonal Antibody(ARB952)

Key features and details

Target: EZHIP
Clone ID: ARB952
Host: Rabbit
Molecular Weight: 51 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Swissprot ID: Q86X51

Brand:

CAT.NO. : ARB6744

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Size:

1mL

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Product Details

Background

EZHIP inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on Lys-27 (H3K27me3). EZHIP limits the enzymatic activity of PRC2 and lessens the interaction between the core complex and its accessory subunits, but does not interfere with PRC2 recruitment to chromatin. Deletion of Ezhip in mice leads to a global increase in H3K27me2/3 deposition both during spermatogenesis and at late stages of oocyte maturation. This does not affect the initial number of follicles but associated with a reduction of follicles in aging.
EZHIP is usually expressed in normal testis tissue and multitumor tissues.
EZHIP is a negative regulator of histone H3 methylation.

Application

Application	Dilution Ratio
IHC	1:100 - 1:200

Overview

Predicted Molecular Wt	51kDa
Species Cross-reactivity	Human
Applications	IHC-P
Purity	ProA affinity purified IgG
Form	Liquid
Swissprot ID	Q86X51
Subcellular location	Nucleus
Recommended Method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%