FHIT Rabbit Monoclonal Antibody(ARA905)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:FHIT
-
Brand:
CAT.NO. : ARA6740
RMB Please choose
RMB Please choose
Product Details
Background
Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. FHIT is also known as human accelerated region 10. It may, therefore, have played a key role in differentiating humans from apes. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies. Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. FHIT also acts as a tumor suppressor of HER2/neu driven breast cancer.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:1000 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Recombinant protein within human FHIT aa 1-147 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IHC-P, FC, IF-Tissue |
|
Molecular Weight |
Predicted band size: 17 kDa |
|
Positive Control |
Jurkat cell lysate, Hela cell lysate, human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, rat kidney tissue lysate, HeLa, human kidney tissue, mouse kidney tissue, rat kidney tissue |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human kidney tissue using FHIT Rabbit Monoclonal Antibody (ARA905)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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