FOXA2 Rabbit Monoclonal Antibody(ARA882)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:FOXA2
-
Brand:
CAT.NO. : ARA6709
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:100-1:1000 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within human FOXA2 aa 1-50/457 |
|
Species Reactivity |
Human, Mouse, Rat (Predicted: Cynomolgus monkey, Pig) |
|
Validated Applications |
WB, IF-Cell, IHC-P, IHC-Fr |
|
Molecular Weight |
Predicted band size: 48 kDa |
|
Positive Control |
HT-29 cell lysate, A549 cell lysate, HepG2 cell lysate, mouse liver tissue, rat liver tissue, HT-29 |
|
Conjugation |
unconjugated |
|
RRID |
AB_3070431 |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical analysis of paraffin-embedded mouse liver tissue with FOXA2 Rabbit Monoclonal Antibody(ARA882)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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