Glypican-3 Mouse Monoclonal Antibody(ARM500)

Key features and details

  • Target: Glypican-3
  • Clone ID: ARM500
  • Host Species: Mouse
  • Species Cross-reactivity: Human
  • Applications: IHC-P
  • Dilution: 1:100-1:500
  • Clonality: Monoclonal
  • Brand:
CAT.NO. : ARM6790
RMB Please choose
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Size:
1mL
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Glypican-3 (GPC3) is a GPI-anchored proteoglycan involved in cell division and growth regulation. Glypican-3 is a useful tumour marker, and its expression has been shown to be upregulated in hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumours, and Wilms’ tumour. Patients with HCC have presented elevated levels of GPC3 in the neoplastic liver tissues and serum, levels which are higher than detected in cirrhotic liver or liver with focal lesions, including those with hepatic adenoma and dysplastic nodules. Glypican-3 is also overexpressed in testicular germ cell tumours of certain subtypes, such as yolk sac tumours and choriocarcinoma, and in embryonal tumours.
Application

Application

Dilution Ratio

IHC

1:100 - 1:500

Overview

Molecular Weight

65,563 Da

Chromosome Location

Chromosome: X; NC_000023.10 (132669773..133119673, complement). Location: Xq26.1

3D Structure

ModBase 3D Structure for P51654

Isotype

IgG1

Host

Mouse

Species Reactivity

Human

Purity/Purification

Purified

Form/Format

Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide

Immunogen

Recombinant Protein

Data

Immunohistochemical staining of human liver tissue using Glypican-3 Mouse Monoclonal Antibody (ARM500).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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