Glypican-3 Rabbit Monoclonal Antibody(ARB961)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6753
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Size:
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Product Details
Background
Glypican 3, also known as GPC3, is a human gene. The protein encoded by this gene is a member of the glypican family. Cell surface heparan sulfate proteoglycans are composed of a membrane - associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican - related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl - phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. Glypican - 3 antibody has been identified to be a useful tumor marker for the diagnosis of Hepatocellular Carcinoma (HCC). Hepatoblastoma, Melanoma, Testicular Germ Cell Tumors, and Wilms Tumor. In patients with HCC, GPC3 was overexpressed in neoplastic liver tissue and detected in serum but was undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression was also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. Glypican - 3 antibody is mainly used in clinical diagnosis of hepatocellular carcinoma.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:100 - 1:200 |
Overview
|
Target |
Glypican-3 |
|
Host Species |
rabbit monoclonal antibody |
|
Molecular Weight |
66 kDa |
|
Purity |
ProA affinity purified IgG |
|
Species Cross-reactivity |
Human |
|
Form |
Liquid |
|
Applications |
IHC-P |
|
Swissprot ID |
P51654 |
|
Immunogen |
Synthetic peptide of Glypican-3 |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
|
Subcellular Location |
Cytoplasm |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 min |
Data
Immunohistochemical staining of human liver cancer tissue sections using Glypican-3 Rabbit Monoclonal Antibody (ARB961).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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