H3K27M Rabbit Monoclonal Antibody(ARB964)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6756
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Size:
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Product Details
Background
H3K27M: encoded by the mutation of a histone H3 gene such as H3F3A. It expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
Diffuse midline glioma, H3K27M - mutant is a lethal brain tumor located in the thalamus, brain stem, or spinal cord. H3K27M plays a pivotal role in the tumorigenesis of this type of glioma. Some results indicated that the H3F3A K27M mutation was found in approximately 80% of diffuse intrinsic pontine gliomas (DIPGs), 50% of thalamic tumors, and 60% of spinal tumors.
H3K27M can be used as an important molecular marker in the diagnosis of diffuse midline gliomas in children and young adults, it is associated with poor prognosis.
Diffuse midline glioma, H3K27M - mutant is a lethal brain tumor located in the thalamus, brain stem, or spinal cord. H3K27M plays a pivotal role in the tumorigenesis of this type of glioma. Some results indicated that the H3F3A K27M mutation was found in approximately 80% of diffuse intrinsic pontine gliomas (DIPGs), 50% of thalamic tumors, and 60% of spinal tumors.
H3K27M can be used as an important molecular marker in the diagnosis of diffuse midline gliomas in children and young adults, it is associated with poor prognosis.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
15kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
P68431 |
|
Subcellular location |
Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human diffuse midline glioma tissue using H3K27M Rabbit Monoclonal Antibody(ARB964)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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