HER2 IHC Rabbit Monoclonal Antibody(ARB820)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6610
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
HER-2 (also called HER-2/neu, c-erbB2, ERBB2 or neu) is a transmembrane receptor tyrosine kinase, which is a proto-oncogene, i.e. its activation causes malignant transformation and increases the malignant potential (cell proliferation, invasiveness etc.) of the cells. In human cancers HER-2 is activated via gene amplification, which is a genomic mutation where a small fragment at chromosome band 17q12-q21 is multiplied in a cell up to 50-100 folds.HER-2 is over-expressed in 15-25% of primary breast cancers, can also be found in intestinal type gastric and gastroesophageal carcinomas, ovarian carcinomas, high grade endometrial carcinomas and some salivary duct tumors. Low-level copy number increases have been found also in rare cases of lung tumors.Studies have shown that c-erbB-2 positive breast cancer usually correlates with negative staining for estrogen and progesterone receptors; thus a poorer predictive outcome is correlated with positive c-erbB-2 staining.
Overview
|
Target |
HER-2 |
|
Host Species |
rabbit monoclonal antibody |
|
Molecular Weight |
138 kDa |
|
Purity |
ProA affinity purified IgG |
|
Species Cross-reactivity |
Human |
|
Form |
Liquid |
|
Applications |
IHC-P |
|
Swissprot ID |
P04626 |
|
Immunogen |
Synthetic peptide corresponding to aa1155-1255 of HER-2 |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
|
Storage Conditions |
-25°C to -18°C |
|
Dilutions |
IHC-P: 1:100-1:200 |
|
Subcellular Location |
Membrane |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18° C-25°C) for 30 minutes |
Data
Immunohistochemical staining of human breast carcinoma tissue sections using HER2 Rabbit Monoclonal Antibody (ARB820).
Immunohistochemical staining of human breast carcinoma (-) tissue sections using HER2 Rabbit Monoclonal Antibody (ARB820).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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