Her3 Mouse Monoclonal Antibody(ARM623)
Key features and details
- Target:
- Clone ID:
- Host:
- Species Cross-reactivity:
- Applications:
- Dilution:
- Clonality:
-
Brand:
CAT.NO. : ARM6914
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Size:
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Product Details
Background
Receptor tyrosine-protein kinase erbB-3, also known as HER-3 (Human Epidermal Growth Factor Receptor 3), is a membrane bound protein and has been shown to bind the ligands heregulin and NRG-2. During human development, HER-3 antibody is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium and is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. HER-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon, and is a reliable marker for aiding in the diagnosis of various cancers by immunohistochemistry.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:50 - 1:200 |
Overview
|
Molecular Weight |
148,098 Da |
|
Chromosome Location |
Chromosome: 12; NC_000012.11 (56473809..56497291). Location: 12q13 |
|
3D Structure |
ModBase 3D Structure for P21860 |
|
Isotype |
IgG2a |
|
Host |
Mouse |
|
Species Reactivity |
Human |
|
Purity/Purification |
Purified |
|
Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
|
Immunogen |
Recombinant Protein |
Data
Immunohistochemical staining of human breast tissue using Her3 Mouse Monoclonal Antibody (ARM623).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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