HHV-8 Mouse Monoclonal Antibody(ARA968)
Key features and details
- Reactivity:This antibody recognizes KSHV ORF45
- Application:IHC-P
- Host:Mouse
- Clonality:Monoclonal
- Target:HHV-8
-
Brand:
CAT.NO. : ARA6831
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Size:
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Product Details
Background
Kaposi's sarcoma-associated herpesvirus (KSHV, Human gammaherpesvirus 8, HHV-8) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200 - 1:1000 |
Overview
|
Reactivity |
Kaposi-Sarkom-Herpesvirus |
|
Host |
Mouse |
|
Clonality |
Monoclonal |
|
Immunogen |
Purified recombinant fragment of KSHV ORF45 expressed in E. Coli. |
|
Specificity |
This antibody recognizes KSHV ORF45 |
|
Isotype |
IgG1 |
|
Formulation |
State: Ascites; State: Ascitic fluid; Preservative: 0.03% Sodium Azide |
|
Conjugation |
Unconjugated |
Data
Immunocytochemistry analysis of TPA induced BCBL-1 cells (A) and uninduced BCBL-1 cells (B) using HHV-8 Mouse Monoclonal Antibody(ARA968) with AEC staining.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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