HIF-1 Alpha Rabbit Monoclonal Antibody(ARM508)
Key features and details
- Target:
- Clone ID:
- Host Species:
- Species Cross-reactivity:
- Applications:
- Dilution:
- Clonality:
-
Brand:
CAT.NO. : ARM6798
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Hypoxia-Inducible Factor 1-Alpha (HIF-1-alpha or HIF1A) is an important mediator of the cellular and systemic responses to hypoxia, promoting survival and maintaining homeostasis in conditions of low oxygen. HIF1A regulates the expression of proteins such as erythropoietin, nitric oxide synthase, and mesenchymal-epidermal transition (MET) receptor, which promote angiogenesis, anaerobic metabolism, and many other survival pathways necessary in hypoxic environments. It has been suggested that tumour hypoxia and the resultant overexpression of MET by HIF1A promotes metastasis, and MET overexpression is correlated with poor prognosis and metastatic disease in the case of breast cancer. HIF-1α expression is associated with cancer progression and clinical outcome in many types of tumours, including breast cancer, type 1 endometrial carcinoma, sarcoma, head and neck tumours, and brain tumours.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:50 - 1:200 |
Overview
|
Molecular Weight |
92,670 Da |
|
Chromosome Location |
Chromosome: 14; NC_000014.8 (62162119..62214977). Location: 14q23.2 |
|
3D Structure |
ModBase 3D Structure for Q16665 |
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Isotype |
IgG |
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Host |
Rabbit |
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Species Reactivity |
Human |
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Purity/Purification |
Purified |
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Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
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Immunogen |
Recombinant Protein |
Data
Immunohistochemical staining of human esophagous cancer tissue using HIF-1 Alpha Rabbit Monoclonal Antibody (ARM508) .
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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