Histone H3 Mutation (Mutated K4M, K9M, K27M, K36M) + H3.3 Mutation (Mutated G34W, G34R, G34V) Antibody Panel, Clone RM191, RM192, RM193, RM363, RM263, RM240, RM307; 31-1327-MP
Key features and details
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Product Details
| Product Name | Histone H3 Mutation (Mutated K4M, K9M, K27M, K36M) + H3.3 Mutation (Mutated G34W, G34R, G34V) Antibody Panel, Clone RM191, RM192, RM193, RM363, RM263, RM240, RM307 |
| Product Description | RevMAb's Antibody Panel of rabbit monoclonal recombinant antibodies to Histone H3.3 G34W, Histone H3.3 G34R, Histone H3.3 G34V, Histone H3 K4M, Histone H3 K9M, Histone H3 K27M, and Histone H3 K36M |
| Catalog No. | 31-1327-MP |
| Clone Name | RM191, RM192, RM193, RM363, RM263, RM240, RM307 |
| Product Data Sheet | Histone H3.3/ H3 Antibody Panel Data Sheet |
| Specificity | Histone H3.3/ H3 Antibody Panel reacts to Histone H3 K27M, K36M, K4M, K9M, along with H3.3 G34W, G34R, and G34V mutants. No cross reactivity with wild type Histone H3. |
| Immunogen | A peptide corresponding to Histone H3 K27M, K36M, K4M, K9M, along with H3.3 G34W, G34R, and G34V mutants individually. |
| Application | Western Blot ELISA Immunohistochemistry |
| Species Reactivity | All |
| Conjugate | None |
| Intended Use | Research Use Only |
| . | |
| Form | Liquid |
| Storage Instructions | Store at -20.0°C |
| Stability | Stable for 1 Year at -20.0°C from date of receipt |
| Storage Buffer | 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Volume/Size | 25 µL each |
| Purity | Protein A affinity purified from an animal origin–free culture supernatant |
| Clone Type | Monoclonal |
| Isotype | Rabbit IgG |
| Usage | Western Blot: 1:125 – 1:1000; ELISA: 1:125 – 1:1000; IHC: 1:100 – 1:500. |
| . | |
 | Immunohistochemical staining of Giant Cell Bone Tumor (GCBT) tissue sections using Anti-Histone H3.3 G34W antibody, Clone RM263. Image courtesy of Adrienne Flanagan, Department of Histopathology, RONH, Stanmore, Middlesex, UK |
| IHC of clinically validated FFPE Glioblastoma tumor tissues with H3.3 G34R expression, using anti-histone H3.3 G34R rabbit monoclonal antibody, Clone RM240. Clinically validated to be Positive for H3.3 G34R Mutation. Image courtesy of Dr. Sebastian Brandner, UCL Institute of Neurology, London, United Kingdom |
 | Immunostaining of brain tumor tissue sections using both EDTA and Citrate pretreatment methods.Clinically validated to be Positive for the H3.3 K27M Mutation by Sanger sequencing. Image courtesy of Sebastian Brandner MD, Division of Neuropathology and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, London, UK |
 | Immunohistochemical staining of formalin fixed paraffin embedded (FFPE) Chondroblastoma tumor cell tissue sections using RM193 Anti-Histone H3 K36M mAb at a 1:400 dilution. Image courtesy of Adrienne Flanagan, Department of Histopathology, RONH, Stanmore, Middlesex, UK |
 | Immunohistochemical staining of Giant Cell Bone Tumor (GCBT) tissue sections using Anti-Histone H3.3 G34V antibody, Clone RM307. Image courtesy of Hidetaka Yamamoto, MD, PhD, Kyushu University, Fukuoka, Japan |
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