HLA-DR Rabbit Monoclonal Antibody(ARA916)
Key features and details
- Reactivity:Human, Mouse
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:HLA-DR
-
Brand:
CAT.NO. : ARA6751
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II α/β dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:50-1:200 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human HLA-DRA aa 159-195 (Extracellular) |
|
Species Reactivity |
Human, Mouse (Predicted: Rat) |
|
Validated Applications |
WB, IF-Cell, IHC-P, FC |
|
Molecular Weight |
Predicted band size: 29 kDa |
|
Positive Control |
Daudi cell lysates, Raji cell lysates, Hela, B16F1, human tonsil tissue, human liver tissue, human spleen tissue, Jurkat |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human tonsil tissue using HLA-DR Rabbit Monoclonal Antibody(ARA916)
Immunohistochemical staining of human liver tissue using HLA-DR Rabbit Monoclonal Antibody(ARA916)
Immunohistochemical staining of human spleen tissue using HLA-DR Rabbit Monoclonal Antibody(ARA916)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
