HLA-G Rabbit Monoclonal Antibody(ARB969)

Key features and details

Target: HLA-G
Clone ID: ARB969
Host: Rabbit
Molecular Weight: 38 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Swissprot ID: P17693

Brand:

CAT.NO. : ARB6761

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Size:

1mL

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Product Details

Background

HLA-G (HLA-G histocompatibility antigen, class I, G) is a non-classical MHC molecule expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors. Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble. It is an inhibitory molecule involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy. HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regulation of natural killer, T, and monocyte/macrophage cells. Its involvement in evasion of immune response makes it a potential target for immunotherapy.
HLA-G is mainly expressed in placental trophoblastic cells and choriocarcinoma cells.

Application

Application	Dilution Ratio
IHC	1:100 - 1:200

Overview

Predicted Molecular Wt	38kDa
Species Cross-reactivity	Human
Applications	IHC-P
Purity	ProA affinity purified IgG
Form	Liquid
Swissprot ID	P17693
Subcellular location	Membrane
Recommended Method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes
Immunogen	Recombinant protein fragment of human HLA-G was used as an immunogen.
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%