HNF1-Beta(HNF1B) Rabbit Monoclonal Antibody(ARA841)
Key features and details
- Target:
- Clone ID:
- Host Species:
- Species Cross-reactivity:
- Applications:
- Dilution:
- Clonality:
- Storage:
-
Brand:
CAT.NO. : ARA6652
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Size:
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Product Details
Background
Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Overview
|
Host |
Rabbit |
|
Isotype |
IgG |
|
Clonality |
Monoclonal |
|
Immunogen |
Human recombinant protein fragment corresponding to the N - terminus of human HNF1 - Beta(HNF1B) (NP_000449) produced in E.coli. |
|
Formulation |
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
|
Concentration |
1 mg/ml |
|
Purification |
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
|
Conjugation |
Unconjugated |
Application
|
Application |
Dilution Ratio |
|
IHC |
1:500-1000 |
Data
Immunohistochemical staining of paraffin - embedded Human kidney tissue within the normal limits using anti - Beta (HNF1B) rabbit monoclonal antibody. Heat - induced epitope retrieval by EDTA solution buffer pH 8.0 at 120°C for 3 min.
Immunohistochemical staining of paraffin - embedded Carcinoma of Human kidney tissue using anti - Beta (HNF1B) rabbit monoclonal antibody. Heat - induced epitope retrieval by EDTA solution buffer pH 8.0 at 120°C for 3 min.
Immunohistochemical staining of paraffin - embedded Human liver tissue within the normal limits using anti - Beta (HNF1B) rabbit monoclonal antibody. Heat - induced epitope retrieval by EDTA solution buffer pH 8.0 at 120°C for 3 min.
Immunohistochemical staining of paraffin - embedded Human pancreas tissue within the normal limits using anti - Beta (HNF1B) rabbit monoclonal antibody. Heat - induced epitope retrieval by EDTA solution buffer pH 8.0 at 120°C for 3 min.
Immunohistochemical staining of paraffin - embedded Human gastric carcinoma using anti - Beta (HNF1B) rabbit monoclonal antibody. Heat - induced epitope retrieval by EDTA solution buffer pH 8.0 at 120°C for 3 min.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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