Human Beta Amyloid 1-40 antibody pair (ARA988/ARA954)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Gene name: MAPT
- Target:Beta Amyloid 1-40
-
Brand:
CAT.NO. : ARA6890
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Size:
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Product Details
Background
Amyloid-beta (1-40), abbreviated as Aβ(1-40), is a 40-residue peptide derived from the amyloid precursor protein (APP) and is involved in the pathogenesis of Alzheimer's disease (AD). It is one of the two main C-terminal variants of the amyloid-beta peptide, along with Aβ(1-42). Both Aβ(1-40) and Aβ(1-42) form aggregates and deposits in the AD brain, contributing to the formation of senile plaques. Unaggregated soluble Aβ(1-40) can also exhibit toxic effects and influence behavior and memory. Additionally, Aβ(1-40) has been shown to interact with synaptic structures such as postsynaptic density-95 (PSD-95), leading to its degradation and affecting synaptic function.
Application
The Beta Amyloid 1-40 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| Beta Amyloid 1-40 Antibody (ARA6886) | ARA988 | Mouse IgG1 | 100μg | Liquid |
| Beta Amyloid Antibody (ARA6798) | ARA954 | Mouse IgG2a | 100μg | Liquid |
| Human beta Amyloid 1-40 polypeptide | AXP6616 | / | 20μg | Liquid |
Overview
|
Antibody pair specificity |
Beta Amyloid 1-40 |
|
Species reactivity |
Human |
|
Protein standard |
Human beta Amyloid 1-40 polypeptide |
|
Target antigen |
Protein name: amyloid beta precursor protein |
|
Cross reactivity |
Not Tested |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6886 at 3 µg/mL as the capture antibody. Recommbinant Beta Amyloid 1-40 protein (ARA6616) was used as the antigen. 1 µg/mL Beta Amyloid Antibody ARA6798 was used as the detection antibody.
Result: ARA6886 and ARA6798 can be used as a matched antibody pair to detect and quantify the concentration of Human Beta Amyloid 1-40 with high specificity.
Storage
Shipped at ambient temperature or with ice packs. Avoid repeated freeze-thaw cycles.
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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