Human Beta Amyloid 1-40 Antibody Pair(ARA954/ARA970)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:Beta Amyloid 1-40
-
Brand:
CAT.NO. : ARA6849
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Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
Background
Amyloid-beta (1-40), abbreviated as Aβ(1-40), is a 40-residue peptide derived from the amyloid precursor protein (APP) and is involved in the pathogenesis of Alzheimer's disease (AD). It is one of the two main C-terminal variants of the amyloid-beta peptide. Along with Aβ(1-42), both Aβ(1-40) and Aβ(1-42) form aggregates and deposits in the AD brain, contributing to the formation of senile plaques. Unaggregated soluble Aβ(1-40) can also exhibit toxic effects and influence memory and behavior. Additionally, Aβ(1-40) has been shown to interact with synaptic structures such as postsynaptic density-95 (PSD-95), leading to its degradation and affecting synaptic function.
Application
The Beta Amyloid 1-40 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Form |
|---|---|---|---|
| Beta Amyloid Antibody | ARA6798 | Mouse IgG2a | Liquid |
| Beta Amyloid 1-40 Antibody | ARA6836 | Mouse IgG1 | Liquid |
| Human beta Amyloid 1-40 polypeptide | AXP6616 | / | Liquid |
Overview
|
Antibody Pair Specificity |
Beta Amyloid 1-40 |
|
Species Reactivity |
Human |
|
Protein Standard |
Human beta Amyloid 1-40 polypeptide |
|
Target Antigen |
Protein name: amyloid beta precursor protein; Gene name: APP; Organism: Homo sapiens (Human) |
|
Cross Reactivity |
Not Tested |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6798 at 2 µg/mL as the capture antibody. Recombinant Beta Amyloid 1-40 protein (Cat #: AXP6616) was used as the antigen. 300 ng/mL biotin conjugated Beta Amyloid 1-40 Antibody (ARA6836) was used as the detection antibody.
Result: ARA6798 and ARA6836 can be used as a matched antibody pair to detect and quantify the concentration of Human Beta Amyloid 1-40 with high specificity.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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