Human beta NGF recombinant protein (Active) (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- 生物活性:
- 活性说明:
- 別名:
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Brand:
CAT.NO. : ARG70145
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human beta NGF recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | beta NGF |
| 物种 | Human |
| A.A. 序列 | Ser122 - Ala241 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce TF-1 cells proliferation. The ED50 for this effect is1 x 10^6 IU/mg. |
| 別名 | HSAN5; Beta-nerve growth factor; Beta-NGF; NGFB |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >98% (by SDS-PAGE) |
| 缓冲液 | 20 mM sodium citrate and 0.2 M NaCl (pH 3.5) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | NGF |
|---|---|
| 全名 | nerve growth factor (beta polypeptide) |
| 背景介绍 | This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
检测图片 (1)
ARG70145 Human beta NGF recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70145 Human beta NGF recombinant protein (Active) (His-tagged, C-ter).
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