Human CCL2 / MCP1 recombinant protein (Active) (His-tagged, N-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- Protein Full name:
- 生物活性:
- 活性说明:
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Brand:
CAT.NO. : ARG70420
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (N-ter) Active Human CCL2 / MCP1 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CCL2 / MCP1 |
| 物种 | Human |
| A.A. 序列 | Gln24 - Thr99 |
| 表达系统 | E. coli |
| Protein Full name | C-C motif chemokine 2 |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to chemoattract BaF3 cells transfected with human CCR2A. The ED50 for this effect is |
| 別名 | CCL2; C-C Motif Chemokine Ligand 2; MCP-1; MCP1; MCAF; HC11; Monocyte Chemotactic And Activating Factor Monocyte Secretory Protein JE; SMC-CF; GDCF-2; SCYA2 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | CCL2 |
|---|---|
| 全名 | C-C Motif Chemokine Ligand 2 |
| 背景介绍 | This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. |
| 生物功能 | Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. |
| 细胞定位 | Secreted |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid |
检测图片 (1)
ARG70420 Human CCL2 / MCP1 recombinant protein (Active) (His-tagged, N-ter) SDS-PAGE image
SDS-PAGE analysis of Human CCL2 / MCP1 recombinant protein (Active) (His-tagged, N-ter)
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