Human CD123 / IL3RA recombinant protein (ECD) (His-tagged, C-ter)
Key features and details
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- 靶点名称:
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CAT.NO. : ARG70252
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Product Details
概述
| 产品描述 | HEK293 expressed, His-tagged (C-ter) Human CD123 / IL3RA recombinant protein (ECD). |
|---|---|
| 反应物种 | Hu |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | CD123 / IL3RA (ECD) |
| 物种 | Human |
| A.A. 序列 | Lys20 - Arg305 of Human CD123 / IL3RA (NP_002174.1) with 6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | IL-3R subunit alpha; CD123; CD antigen CD123; IL3RAY; IL-3R-alpha; IL3RY; IL3RX; IL3R; IL-3RA; IL-3 receptor subunit alpha; hIL-3Ra; Interleukin-3 receptor subunit alpha |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL3 at 4µg/ml (100µl/well) can bind recombinant Human IL3RA, the EC50 of Human IL3RA is 5.3 µg/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 90% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P26951 Human Interleukin-3 receptor subunit alpha |
|---|---|
| 基因名称 | IL3RA |
| 全名 | interleukin 3 receptor, alpha (low affinity) |
| 背景介绍 | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
| 生物功能 | This is a receptor for interleukin-3. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 43 kDa |
检测图片 (1)
ARG70252 Human CD123 / IL3RA recombinant protein (ECD) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70252 Human CD123 / IL3RA recombinant protein (ECD) (His-tagged, C-ter).
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