Human CD124 / IL4 Receptor ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG81315
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Product Details
概述
| 产品描述 | ARG81315 Human CD124 / IL4 Receptor ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human CD124 / IL4 Receptor in serum, plasma and cell culture supernatant. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | Recognizes both natural and recombinant Human soluble IL4 Receptor. No cross reactivity with other Human soluble receptors. |
| 靶点名称 | CD124 / IL4 Receptor |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 11.5 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 31.25 - 1000 pg/ml |
| 样本量 | 100 µl |
| 別名 | CD124; IL-4RA; IL-4R subunit alpha; Soluble IL-4R-alpha; IL-4 receptor subunit alpha; IL4RA; CD antigen CD124; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; IL-4R-alpha; IL-4-binding protein; IL4-BP; Interleukin-4 receptor subunit alpha |
应用说明
| 检测时间 | ~ 2 hours |
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属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P24394 Human Interleukin-4 receptor subunit alpha |
|---|---|
| 基因名称 | IL4R |
| 全名 | interleukin 4 receptor |
| 背景介绍 | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
| 生物功能 | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. [UniProt] |
| 产品亮点 | Related products: CD124 ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. [UniProt] |
检测图片 (1)
ARG81315 Human CD124 / IL4 Receptor ELISA Kit standard curve image
ARG81315 Human CD124 / IL4 Receptor ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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