Human CD130 ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG81316
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Product Details
概述
| 产品描述 | ARG81316 Human CD130 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human CD130 in serum, plasma and cell culture supernatant. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | Recognizes both natural and recombinant Human soluble CD130. No cross reactivity with other Human soluble receptors. No interference with neither soluble gp80 nor IL-6. |
| 靶点名称 | CD130 / gp130 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 15 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 56.25 - 1800 pg/ml |
| 样本量 | 100 µl |
| 別名 | CDw130; CD130; CDW130; Interleukin-6 signal transducer; CD antigen CD130; IL-6RB; Membrane glycoprotein 130; GP130; Oncostatin-M receptor subunit alpha; IL-6R subunit beta; Interleukin-6 receptor subunit beta; gp130; IL-6 receptor subunit beta; IL-6R-beta |
应用说明
| 检测时间 | ~ 2 hours |
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属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P40189 Human Interleukin-6 receptor subunit beta |
|---|---|
| 基因名称 | IL6ST |
| 全名 | interleukin 6 signal transducer |
| 背景介绍 | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] |
| 生物功能 | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. [UniProt] |
| 产品亮点 | Related products: CD130 antibodies; CD130 ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | Phosphorylation of Ser-782 down-regulates cell surface expression. Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009). [UniProt] |
检测图片 (1)
ARG81316 Human CD130 ELISA Kit standard curve image
ARG81316 Human CD130 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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