Human CD137 recombinant protein (ECD) (Fc-His-tagged, C-ter)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- 別名:
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Brand:
CAT.NO. : ARG70291
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Product Details
概述
| 产品描述 | HEK293 expressed, Fc-His-tagged (C-ter) Human CD137 recombinant protein (ECD). |
|---|---|
| 反应物种 | Hu |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | CD137 (ECD) |
| 物种 | Human |
| A.A. 序列 | Leu24 - Gln186 of Human CD137 (NP_001552) with an Fc-6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | ILA; CD137; T-cell antigen 4-1BB homolog; CDw137; T-cell antigen ILA; 4-1BB; CD antigen CD137; Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized human TNFSF9 at 2 µg/ml (100 µl/well) can bind Human 4-1BB/CD137, the EC50 of Human 4-1BB/CD137 is 40-100 ng/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 97% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q07011 Human Tumor necrosis factor receptor superfamily member 9 |
|---|---|
| 基因名称 | TNFRSF9 |
| 全名 | tumor necrosis factor receptor superfamily, member 9 |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 28 kDa |
检测图片 (1)
ARG70291 Human CD137 recombinant protein (ECD) (Fc-His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70291 Human CD137 recombinant protein (ECD) (Fc-His-tagged, C-ter).
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