Human CD153 / CD30 Ligand recombinant protein (Active) (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
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- Protein Full name:
- 生物活性:
- 活性说明:
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Brand:
CAT.NO. : ARG70470
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human TNFSF8 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CD153 / CD30 Ligand |
| 物种 | Human |
| A.A. 序列 | Gln63 - Asp234 |
| 表达系统 | E. coli |
| Protein Full name | Tumor necrosis factor ligand superfamily member 8 |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce IL-8 secretion in human PBMCs using a concentration range of 10 - 100 ng/mL. Note: Results may vary from different PBMC donors. |
| 別名 | TNFSF8; TNF Superfamily Member 8; CD30LG; CD153; Tumor Necrosis Factor (Ligand) Superfamily, Member 8; Tumor Necrosis Factor Ligand Superfamily Member 8; CD153 Antigen; CD30 Ligand; CD30-L; CD30L; Tumor Necrosis Factor Superfamily Member 8; Tumor Necrosis Factor Ligand 3A; CD30 Antigen Ligand; TNLG3A |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >98% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | TNFSF8 |
|---|---|
| 全名 | TNF Superfamily Member 8 |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. |
| 生物功能 | Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. |
| 细胞定位 | Membrane |
| 翻译后修饰 | Disulfide bond, Glycoprotein |
检测图片 (1)
ARG70470 Human CD153 / CD30 Ligand recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70470 Human CD153 / CD30 Ligand recombinant protein (Active) (His-tagged, C-ter)
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