Human CD279 / PD-1 recombinant protein (His-tagged)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
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- Protein Full name:
- 別名:
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Brand:
CAT.NO. : ARG70507
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Product Details
概述
| 产品描述 | CHO expressed, His-tagged Human CD279 / PD-1 recombinant protein. |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CD279 / PD-1 |
| 物种 | Human |
| A.A. 序列 | Met1-Gln167 |
| 表达系统 | CHO |
| Protein Full name | Programmed cell death protein 1 |
| 別名 | PDCD1; Programmed Cell Death 1; PD1; CD279; HSLE1; PD-1; Systemic Lupus Erythematosus Susceptibility 2; Programmed Cell Death Protein 1; Protein PD-1; SLEB2; HPD-1; Programmed Cell Death 1 Protein; CD279 Antigen; HPD-L |
属性
| 形式 | Powder |
|---|---|
| 纯化 | >95% (by SDS-PAGE) |
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | PDCD1 |
|---|---|
| 全名 | Programmed Cell Death 1 |
| 背景介绍 | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] |
| 生物功能 | The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. [Uniprot] |
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