Human CD358 / DR6 ELISA Kit
Key features and details
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- 反应物种:
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- 靶点名称:
- 偶联标记:
- 偶联标记说明:
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Brand:
CAT.NO. : ARG82467
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Product Details
内含物
| 货号 | 内含物名称 | 包装 | 温度 |
|---|---|---|---|
| ARG82467-001 | Antibody-coated microplate | 8 X 12 strips | 4°C. Unused strips should be sealed tightly in the air-tight pouch. |
| ARG82467-002 | Standard | 2 X 10 ng/vial | 4°C |
| ARG82467-003 | Standard/Sample diluent | 30 ml (Ready to use) | 4°C |
| ARG82467-004 | Antibody conjugate concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG82467-005 | Antibody diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG82467-006 | HRP-Streptavidin concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG82467-007 | HRP-Streptavidin diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG82467-008 | 25X Wash buffer | 20 ml | 4°C |
| ARG82467-009 | TMB substrate | 10 ml (Ready to use) | 4°C (Protect from light) |
| ARG82467-010 | STOP solution | 10 ml (Ready to use) | 4°C |
| ARG82467-011 | Plate sealer | 4 strips | Room temperature |
概述
| 产品描述 | ARG82467 Human CD358 / DR6 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human CD358 / DR6 in serum, plasma (EDTA, heparin, citrate) and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | CD358 / DR6 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 10 pg/ml |
| 样品类型 | Serum, plasma (EDTA, heparin, citrate) and cell culture supernatants. |
| 标准范围 | 15.6 - 1000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: 4.9% Inter-Assay CV: 5.5% |
| 別名 | CD antigen CD358; CD358; Tumor necrosis factor receptor superfamily member 21; DR6; Death receptor 6; BM-018 |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O75509 Human Tumor necrosis factor receptor superfamily member 21 |
|---|---|
| 基因名称 | TNFRSF21 |
| 全名 | tumor necrosis factor receptor superfamily, member 21 |
| 背景介绍 | This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013] |
| 生物功能 | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 产品亮点 | Related products: CD358 antibodies; CD358 ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
检测图片 (1)
ARG82467 Human CD358 / DR6 ELISA Kit standard curve image
ARG82467 Human CD358 / DR6 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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