Human CD38 recombinant protein (ECD) (His-tagged, C-ter)
Key features and details
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- 靶点名称:
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- 別名:
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Brand:
CAT.NO. : ARG70261
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Product Details
概述
| 产品描述 | HEK293 expressed, His-tagged (C-ter) Human CD38 recombinant protein (ECD). |
|---|---|
| 反应物种 | Hu |
| 应用 | Binding, ELISA, SDS-PAGE |
| 靶点名称 | CD38 (ECD) |
| 物种 | Human |
| A.A. 序列 | Val43 - Ile300 of Human CD38 (NP_001766.2) with 6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | cADPr hydrolase 1; ADPRC 1; EC 3.2.2.6; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; Cyclic ADP-ribose hydrolase 1; ADPRC1; EC 2.4.99.20; ADP-ribosyl cyclase 1; 2'-phospho-cyclic-ADP-ribose transferase; CD antigen CD38; T10; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD38 at 0.5 ug/ml (100 µl/well) can bind CD38 antibody with a linear range of 2-10 ng/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P28907 Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
|---|---|
| 基因名称 | CD38 |
| 全名 | CD38 molecule |
| 背景介绍 | The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| 生物功能 | Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. [UniProt] |
| 细胞定位 | Membrane; Single-pass type II membrane protein. [UniProt] |
| 预测分子量 | 34 kDa |
检测图片 (2)
ARG70261 Human CD38 recombinant protein (ECD) (His-tagged, C-ter) ELISA image
ELISA: The plate was coated with ARG70261 Human CD38 recombinant protein (ECD) (His-tagged, C-ter) at 0.5 µg/ml (100 µl/well). Samples were detected with serially diluted anti-CD38 antibody.
ARG70261 Human CD38 recombinant protein (ECD) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70261 Human CD38 recombinant protein (ECD) (His-tagged, C-ter).
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