Human Corin ELISA Kit
Key features and details
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- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG81545
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Product Details
内含物
| 货号 | 内含物名称 | 包装 | 温度 |
|---|---|---|---|
| ARG81545-001 | Antibody-coated microplate | 8 X 12 strips | 4°C. Unused strips should be sealed tightly in the air-tight pouch. |
| ARG81545-002 | Standard | 2 X 10 ng/vial | 4°C |
| ARG81545-003 | Standard/Sample diluent | 30 ml (Ready to use) | 4°C |
| ARG81545-004 | Antibody conjugate concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81545-005 | Antibody diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81545-006 | HRP-Streptavidin concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81545-007 | HRP-Streptavidin diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81545-008 | 25X Wash buffer | 20 ml | 4°C |
| ARG81545-009 | TMB substrate | 10 ml (Ready to use) | 4°C (Protect from light) |
| ARG81545-010 | STOP solution | 10 ml (Ready to use) | 4°C |
| ARG81545-011 | Plate sealer | 4 strips | Room temperature |
概述
| 产品描述 | ARG81545 Human Corin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Corin in serum, plasma (heparin, EDTA) and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | Corin |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 31.25 pg/ml |
| 样品类型 | Serum, plasma (heparin, EDTA) and cell culture supernatants. |
| 标准范围 | 62.5 - 4000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: 6.2% Inter-Assay CV: 6.9% |
| 別名 | Pro-ANP-converting enzyme; ATC2; Lrp4; Heart-specific serine proteinase ATC2; Transmembrane protease serine 10; Corin; TMPRSS10; EC 3.4.21.-; CRN; Atrial natriuretic peptide-converting enzyme; PEE5 |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9Y5Q5 Human Atrial natriuretic peptide-converting enzyme |
|---|---|
| 基因名称 | CORIN |
| 全名 | corin, serine peptidase |
| 背景介绍 | This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] |
| 生物功能 | Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared to isoform 1. [UniProt] |
| 产品亮点 | Related products: New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | N-glycosylated; required for processing and activation. Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1. A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments). [UniProt] |
检测图片 (1)
ARG81545 Human Corin ELISA Kit standard curve image
ARG81545 Human Corin ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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