Human GDF6 recombinant protein (Active) (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
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- A.A. 序列:
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- 別名:
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Brand:
CAT.NO. : ARG70099
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human GDF6 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | GDF6 |
| 物种 | Human |
| A.A. 序列 | Thr336 - Arg455 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is 63-240 ng/mL. |
| 別名 | BMP13; SCDO4; KFS; KFS1; MCOP4; Growth/differentiation factor 6; Bone morphogenetic protein 13; SGM1; BMP-13; LCA17; Growth/differentiation factor 16; KFSL; KFM; GDF-6; CDMP2; MCOPCB6 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >98% (by SDS-PAGE) |
| 缓冲液 | 20 mM sodium citrate and 0.2 M NaCl (pH 3.5) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | GDF6 |
|---|---|
| 全名 | growth differentiation factor 6 |
| 背景介绍 | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
检测图片 (1)
ARG70099 Human GDF6 recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70099 Human GDF6 recombinant protein (Active) (His-tagged, C-ter).
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